Died [March 1863] at his residence in Bradford township of paralytic disease, John Shirey, sen., aged 64 years, 1 month and 23 days. The deceased was among the early settlers of the county, and one of our most --- and respected citizens.2523

[Is this the same John?]
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Married on Thursday the 13th inst., [April 1848] by James M. Shaw, Esq., Mr. John W. Kylar, to Miss Sophia Shirey, all of Bradford township. [Could Sophia be a daughter of John and Nancy’s?]2428

Note: There is a biography of John Kyler who married Sophia Shirey, daughter of John at this source.585